Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 26, Pages 7620-7624Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201703276
Keywords
copolymers; drug delivery; nanomotors; redox sensitivity; self-assembly
Categories
Funding
- ERC under European Union [ERC-StG 307679]
- Ministry of Education, Culture and Science [024.001.035]
- NWO Chemiche Wetenschappen VIDI grant [723.015.001]
- China scholarship council
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The development of artificial nanomotor systems that are stimuli-responsive is still posing many challenges. Herein, we demonstrate the self-assembly of a redox-responsive stomatocyte nanomotor system, which can be used for triggered drug release under biological reducing conditions. The redox sensitivity was introduced by incorporating a disulfide bridge between the hydrophilic poly(ethylene glycol) block and the hydrophobic polystyrene block. When incubated with the endogenous reducing agent glutathione at a concentration comparable to that within cells, the external PEG shells of these stimuli-responsive nanomotors are cleaved. The specific bowl-shaped stomatocytes aggregate after the treatment with glutathione, leading to the loss of motion and triggered drug release. These novel redox-responsive nanomotors can not only be used for remote transport but also for drug delivery, which is promising for future biomedical applications.
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