Journal
PHYSICAL REVIEW E
Volume 95, Issue 6, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.95.062404
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Funding
- National Natural Science Foundation of China [11374282, 21573214, 11402265]
- Fundamental Research Funds for the Central Universities [WK2030020023, WK2030020028]
- Anhui Natural Science Foundation [1408085MA10]
- Chinese government 1000 Youth Talent Program
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Cells can adjust to their growth environments and regulate their behavior accordingly. To study how cells accomplish this growth-dependent adjustment from the molecular to the behavioral level, we used bacterial chemotaxis as a model system to explore the behavioral difference for bacteria grown in nutrient-rich and nutrient-poor media. We found that bacteria grown in a nutrient-poor medium exhibit faster chemotaxis adaptation, and this enables them to respond more rapidly to a changing environment and increases their ability to localize to a nutrient concentration peak. We identified the molecular mechanisms behind this behavioral difference through coarse-grained modeling, and demonstrated its physiological consequences by simulating bacterial chemotactic motion in spatiotemporally varying environments and in a static environment with a nutrient concentration peak.
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