Journal
RSC ADVANCES
Volume 7, Issue 39, Pages 24291-24297Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra02626a
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Funding
- National Natural Science Foundation of China [81503086, 21672161, 81673647]
- Tianjin University of Science & Technology (TUST), a research funding of 1000 Talents Plan of Tianjin [20140520]
- Foundation of Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education
- Tianjin Key Lab of Industrial Microbiology [2015IM106]
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Autophagy is a highly conserved cellular process in eukaryotic cells, which allows the orderly degradation and recycling of cellular components via lysosomal pathway. It is believed that autophagy is highly relevant to oncogenes and oncotherapy. Increasing evidence suggests that pharmacological modulation, especially inhibition of autophagy is a promising therapeutic strategy for cancers. In current study, we have demonstrated that the saponins fraction (Conyza blinii saponins, CBS) isolated from a medicinal plant Conyza blinii H.Lev. is a dual-targeting autophagy inhibitor for HeLa cells. The inhibition effect of CBS is derived from its mTOR activation and autophagic degradation blockage effects. Our novel finding not only expands the bio-activity spectrum of saponins but also creates potential for anti-cancer drug development.
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