Journal
RSC ADVANCES
Volume 7, Issue 39, Pages 24338-24344Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra28754a
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Funding
- Chinese Ministry of Science and Technology [2012BAK04B03]
- National 973 Program of China [2015CB755401]
- Chongqing Science and Technology Commission [cstc2013jcyjC00001, cstc2013yykfC00007]
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Terahertz (THz) spectroscopic techniques were employed to study the hydration shell formation around anti-estrogen receptor alpha (AER-alpha), an important biomarker in breast cancer diagnosis, and to detect the binding reaction between AER-alpha and estrogen receptor peptide alpha (ERP-alpha), in aqueous solutions. A remarkable nonlinear relation between THz absorption and AER-alpha concentration was demonstrated, shedding some light on the formation process of the hydration shell around AER-alpha. THz spectroscopic properties of the AER-alpha were also shown to be significantly affected by the binding with the ERP-alpha, to the extent that THz transmission and attenuation could be used to investigate the dielectric properties of antibody-antigen binding reactions.
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