Journal
CARBOHYDRATE POLYMERS
Volume 170, Issue -, Pages 99-106Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.04.073
Keywords
Ionic liquid; Hydrogel; Chitosan; Chondroitin sulfate
Categories
Funding
- CNPq
- Capes
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[Hmim][HSO4] ionic liquid (IL) and bio-renewable sources as chitosan (CHT) and chondroitin sulfate (CS) were used to yield hydrogel-based materials (CHT/CS). The use of IL to solubilize both polysaccharides was considered an innovative way based on green chemistry principle, aiming the production of CHT/CS blended systems. CHT/CS hydrogels were carried out in homogeneous medium from short dissolution times. The hydrogels were characterized and achieved with excellent stabilities (in the 1.2-10 pH range), larger swelling capacities, as well as devoid of cytotoxicity towards the normal VERO and diseased HT29 cells. The CHT/CS hydrogels carried out in [Hmim][HSO4] could be applied in many technological purposes, like medical, pharmaceutical, and environmental fields. (C) 2017 Elsevier Ltd. All rights reserved.
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