4.7 Article

Rh(III)-Catalyzed bilateral cyclization of aldehydes with nitrosos toward unsymmetrical acridines proceeding with C-H functionalization enabled by a transient directing group

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 46, Pages 6263-6266

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc03006a

Keywords

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Funding

  1. National Natural Science Foundation of China [21572025, 21602019]
  2. Innovation & Entrepreneurship Talents'' Introduction Plan of Jiangsu Province
  3. Key University Science Research Project of Jiangsu Province [15KJA150001]
  4. Jiangsu Key Laboratory of Advanced Catalytic Materials Technology [BM2012110]
  5. Advanced Catalysis and Green Manufacturing Collaborative Innovation Center
  6. Young Natural Science Foundation of Jiangsu Province [BK20150263]

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A Rh(III)-catalyzed bilateral cyclization was developed for the efficient construction of acridines proceeding with C-H functionalization whereby in situ formation and removal of an imino transient directing group in the presence of catalytic amount of BnNH2 are achieved. In this transformation, a sequential Rh(III)-catalyzed C-H amination, cyclization, and aromatization process was involved.

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