4.7 Article

Stimulated Raman scattering of polymer nanoparticles for multiplexed live-cell imaging

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 46, Pages 6187-6190

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc01860f

Keywords

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Funding

  1. NIH Director's New Innovator Award, NIH R01 [EB020892]
  2. Alfred P. Sloan Foundation
  3. Henry Dreyfus Foundation
  4. National Science Foundation (NSF) [CAREER DMR-1351293]
  5. ACS Petroleum Research Fund
  6. 3 M Non-Tenured Faculty Award
  7. NSF GRFP [DGE-16-44869]
  8. NSF [CHE1464992]
  9. Camille and Henry Dreyfus Foundation
  10. ARO MURI [W911NF-12-1-0594]
  11. Division Of Chemistry
  12. Direct For Mathematical & Physical Scien [1464992] Funding Source: National Science Foundation

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A novel nanoparticle-based imaging strategy is introduced that couples biocompatible organic nanoparticles and stimulated Raman scattering (SRS) microscopy. Polymer nanoparticles with vibrational labels incorporated were readily prepared for multi-color SRS imaging with excellent photo-stability. The Raman-active polymer dots are nontoxic, rapidly enter various cell types, and are applied in multiplexed cell-type sorting.

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