Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 46, Pages 6271-6274Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc03477f
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Funding
- University of Utah
- Huntsman Cancer Institute
- USTAR initiative
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A novel class of bioorthogonal release reactions based on benzonorbornadiene derivatives was developed. These carrier molecules are highly stable at physiological conditions, but react rapidly with 1,2,4,5-tetrazines, and near-quantitatively release cargo molecules such as drugs and optical reporters.
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