Journal
AGING MALE
Volume 20, Issue 2, Pages 115-118Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13685538.2017.1284778
Keywords
Benign Prostatic hyperplasia; angiopoietin-2; angiogenesis; interleukin-17; inflammation
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Funding
- JIPMER
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Introduction: Inflammation and angiogenesis are known to play a role in the development prostate tumors. The present study was designed to assess the levels of markers of inflammation and angiogenesis like interleukin-17 (IL-17) and angiopoietin-2 (ANGPT2) levels and their association with prostate size in patients with benign prostatic hyperplasia (BPH).Materials and methods: 42 BPH cases and 42 controls were enrolled in the study. IL-17 and ANGPT2 were estimated in both the groups.Results: IL-17 and ANGPT2 were significantly increased in BPH cases when compared with controls. Multivariate analysis showed that ANGPT2 predicts the prostate size in patients with BPH (R-2=0.203, beta=0.355, p=0.028). Linear regression analysis showed that IL-17 was significantly associated with ANGPT2 in BPH cases (R-2=0.129, beta - 0.359, p=0.020).Conclusions: We conclude that IL-17 and ANGPT2 are elevated in BPH cases and ANGPT2 was associated with IL-17 and prostate size.
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