Journal
ACTA OTO-LARYNGOLOGICA
Volume 137, Issue -, Pages S2-S7Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00016489.2017.1300321
Keywords
Single-sided deafness; asymmetrical hearing loss; cochlear nerve deficiency; cytomegalovirus; mumps; inner ear anomaly; auditory neuropathy spectrum disorder; idiopathic sensorineural hearing loss; cochlear implant
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Funding
- Health and Labour Sciences Research from Ministry of Health, Labour and Welfare, Japan
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Conclusions: The present study revealed that various etiologies are involved in single-sided deafness (SSD), and that the cause of SSD and asymmetrical hearing loss (AHL) differed greatly between congenital/ early-onset cases and adult cases. Clarification of the etiology is the first step toward providing appropriate intervention. Objectives: The study aimed to clarify the etiology of SSD and AHL patients. Methods: The etiology of a total of 527 SSD or AHL patients who visited Shinshu University Hospital between 2006 and 2016 were analyzed by imaging as well as serological tests for mumps virus, and CMV DNA testing. Results: In our cohort of congenital/early-onset SSD (n = 210), the most prevalent cause in children was cochlear nerve deficiency (43.7%; 87 of 199 patients undergoing CT and/or MRI), followed by CMV infection, mumps infection, anomalies of the inner ear, ANSD, and other rare etiologies. In contrast, half of the adult SSD patients presented with idiopathic sensorineural hearing loss, followed by various types of otitis media, cerebellopontine angle tumor and other rare etiologies.
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