Journal
ONCOTARGET
Volume 8, Issue 67, Pages 112051-112059Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.23002
Keywords
curcumin; myocardial ischemia-reperfusion; inflammation
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Funding
- Six Talent Peaks Project in Jiangsu Province, China [2014-YY-006, 2016-WSN-103]
- China Postdoctoral Science Foundation of China [2013M541705]
- Postdoctoral Research Foundation of Jiangsu Province, China [1301072C]
- Science Foundation of Nantong City, Jiangsu Province, China [MS32015016, MS32015030]
- Natural Science Foundation of Jiangsu Province, China [BK20171257]
- 333 Project of Jiangsu Province, China [BRA2017557]
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Background: Cardiovascular diseases (CVDs) are at a badly high-risk of morbidity and mortality in the world. Methods: Our study was attempted to investigate the cardioprotective role of curcumin. Hearts injury was assessed in isolated hearts and the rats of coronary artery ligated. Results and Conclusions: The inhibition of pro-inflammatory cytokines was observed by curcumin in coronary artery ligated rats. ST segment was also reduced by curcumin. Triphenyltetrazolium chloride staining (TTC) staining and pathological analysis were also showed that curcumin could dramatically alleviate myocardial injury. Besides, the results in vitro also demonstrated that curcumin could improved the function of isolated hearts. Besides, the expressions of inflammation-related pathway in both rats and isolated hearts treated with curcumin were significantly decreased. The present study investigated the protective effects of curcumin on myocardial injury and its mechanism.
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