Journal
ONCOTARGET
Volume 8, Issue 19, Pages 32147-32156Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.16740
Keywords
gastrodin; LPS; Nrf2; lung injury
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Funding
- Education Department of Sichuan Province [13ZB0267]
- Joint Research Fund for Luzhou Technology Bureau and Luzhou Medical College [14JC0181, 2013LZLY-J52]
- Science and Technology Agency of Sichuan [2014SZ0071]
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Gastrodin (GAS), a phenolic glucoside derived from Gastrodiaelata Blume, has been reported to have anti-inflammatory effect. The aim of this study was to investigate the effects of GAS on LPS-induced acute lung injury in mice. ALI was induced by the intranasal administration of LPS and GAS was given 1 h or 12 h after LPS treatment. The results indicated that GAS treatment markedly attenuated the damage of lung injury induced by LPS. GAS attenuated the activity of myeloperoxidase (MPO) and down-regulated the levels of pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1 beta in BALF. LPS-induced lung edema and lung function were also reversed by GAS. Furthermore, GAS was found to inhibit LPS-induced inflammatory cells infiltration. In addition, treatment of GAS inhibited LPS-induced NF-kappa B activation and up-regulated the expression of Nrf2 and HO-1. In conclusion, our results indicated that GAS had anti-inflammatory effects on LPS-induced acute lung injury. The anti-inflammatory mechanism of GAS was through the inhibition of NF-kappa B and activation of Nrf2 signaling pathways.
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