Journal
ONCOTARGET
Volume 8, Issue 36, Pages 60704-60709Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.19610
Keywords
PPARs; ligands; cancer therapy; cell signaling
Categories
Funding
- National Natural Science Foundation of China [81672711]
- Wujin Sci Tech Progran [WS201505]
- innovative and entrepreneurial talent of Jiangsu Province
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Peroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors including PPAR alpha, PPAR delta and PPAR gamma, which play an important role in regulating cancer cell proliferation, survival, apoptosis, and tumor growth. Activation of PPARs by endogenous or synthetic compounds regulates tumor progression in various tissues. Although each PPAR isotype suppresses or promotes tumor development depending on the specific tissues or ligands, the mechanism is still unclear. In this review, we summarized the regulative mechanism of PPARs on cancer progression.
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