Journal
BRITISH JOURNAL OF CANCER
Volume 116, Issue 12, Pages 1627-1637Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2017.120
Keywords
ovarian cancer; survival; mortality; diet; nutrients; dietary supplements
Categories
Funding
- U.S. Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- National Health and Medical Research Council (NHMRC) of Australia [400281, 400413, 199600]
- Cancer Council of Victoria
- Cancer Foundation of Western Australia
- National Cancer Institute Cancer Prevention Training Grant [T32 CA105666]
- Australian Postgraduate Award
- NHMRC Program Grant [552429]
- NHMRC
- Cancer Council of Queensland
- Cancer Council of New South Wales
- Cancer Council of South Australia
- Cancer Council of Tasmania
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Background: The relationship between diet and survival after ovarian cancer diagnosis is unclear as a result of a limited number of studies and inconsistent findings. Methods: We examined the association between pre-diagnostic diet and overall survival in a population-based cohort (n = 811) of Australian women diagnosed with invasive epithelial ovarian cancer between 2002 and 2005. Diet was measured by validated food frequency questionnaire. Deaths were ascertained up to 31 August 2014 via medical record review and Australian National Death Index linkage. We conducted Cox proportional hazards regression analysis, controlling for diagnosis age, tumour stage, grade and subtype, residual disease, smoking status, body mass index, physical activity, marital status, and energy intake. Results: We observed improved survival with highest compared with lowest quartile of fibre intake (hazard ratio (HR) = 0.69, 95% CI: 0.53-0.90, P-trend = 0.002). There was a suggestion of better survival for women with highest compared with lowest intake category of green leafy vegetables (HR = 0.79, 95% CI: 0.62-0.99), fish (HR = 0.74, 95% CI: 0.57-0.95), poly-to mono-unsaturated fat ratio (HR = 0.76, 95% CI: 0.59-0.98), and worse survival with higher glycaemic index (HR = 1.28, 95% CI: 1.01-1.65, P-trend = 0.03). Conclusions: The associations we observed between healthy components of diet pre-diagnosis and ovarian cancer survival raise the possibility that dietary choices after diagnosis may improve survival.
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