Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume -, Issue 27, Pages 4510-4517Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201500643
Keywords
Nanoparticles; Cerium; Toxicity; Antioxidants; Radiation protection; Experimental design
Categories
Funding
- Swiss National Science Foundation [NRP-62]
- University of Fribourg
- Fribourg Center for Nanomaterials
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Nanoceria (cerium oxide nanoparticles) toxicity is currently a concern because of its use in motor vehicles in order to reduce carbon monoxide (CO), nitrogen oxides (NOx), and hydrocarbons in exhaust gases. In addition, many questions arise with respect to its biomedical applications exploiting its potential to protect cells against irradiation and oxidative stress. Indeed, toxicology studies on nanoceria report results that seem contradictory, demonstrating toxic effects in some studies, protective effects in others, and sometimes little or no effect at all. The variability in the experimental setups and particle characterization makes these studies difficult to compare and the toxicity of newly developed nanoceria materials challenging to predict. This microreview aims to compare the toxicity of nanoceria in terms of preparation method, particle size, concentration, host organism, and exposure method.
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