Journal
ONCOTARGET
Volume 8, Issue 48, Pages 84546-84558Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.19165
Keywords
thrombospondin-1; tumor progression; tumor angiogenesis; cancer cell behavior; tumor immunity
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Funding
- National Natural Science Foundation of China [81372664]
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Thrombospondins are a family of extracellular matrix (ECM) proteins. Thrombospondin-1 (TSP1) was the first member to be identified and is a main player in tumor microenvironment. The diverse functions of TSP1 depend on the interactions between its structural domains and multiple cell surface molecules. TSP1 acts as an angiogenesis inhibitor by stimulating endothelial cell apoptosis, inhibiting endothelial cell migration and proliferation, and regulating vascular endothelial growth factor bioavailability and activity. In addition to angiogenesis modulation, TSP1 also affects tumor cell adhesion, invasion, migration, proliferation, apoptosis and tumor immunity. This review discusses the multifaceted and sometimes opposite effects of TSP1 on tumor progression depending on the molecular and cellular composition of the microenvironment. Clinical implications of TSP1-related compounds are also discussed.
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