Journal
ONCOTARGET
Volume 8, Issue 46, Pages 81558-81571Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.18277
Keywords
epithelial-to-mesenchymal transition; circulating tumor cells; metastasis; EMT markers
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Funding
- Key Project for Major Diseases of Health System of Shanghai Municipality [2013ZYJB0201]
- National Key Research and Development Program [2016YFC1303100]
- National Natural Sciences Foundation of China [81472424]
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Epithelial-to-mesenchymal transition (EMT) endows epithelial cells with enhanced motility and invasiveness, allowing them to participate in many physiological and pathological processes. Epithelial-to-mesenchymal transition contributes to the generation of circulating tumor cells (CTCs) in epithelial cancers because it increases tumor cell invasiveness, promotes tumor cell intravasation and ensures tumor cell survival in the peripheral system. Although the contribution of epithelial-to-mesenchymal transition to tumor cell invasiveness has been confirmed, the role epithelial-to-mesenchymal transition plays in metastasis remains debated. As a favorable material for a liquid biopsy, circulating tumor cells have been shown to have promising values in the clinical management of tumors. Furthermore, an increasing number of studies have begun to explore the value of CTC-related biomarkers, and some studies have found that the expression of EMT and stemness markers in circulating tumor cells, in addition to CTC detection, can provide more information on tumor diagnosis, treatment, prognosis and research.
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