Journal
ONCOTARGET
Volume 8, Issue 34, Pages 57813-57825Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.18175
Keywords
the Warburg effect; the reverse Warburg effect; cancer glucose metabolism; lactate shuttle; oxidative stress
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Funding
- National Natural Science Foundation of China [81328019, 81572748]
- Natural Science Foundation of Hunan Province [2015JJ2148]
- Central South University [CX2016346]
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Although survival outcomes of cancer patients have been improved dramatically via conventional chemotherapy and targeted therapy over the last decades, there are still some tough clinical challenges that badly needs to be overcome, such as anticancer drug resistance, inevitable recurrences, cancer progression and metastasis. Simultaneously, accumulated evidence demonstrates that aberrant glucose metabolism termed 'the Warburg effect' in cancer cell is closely associated with malignant phenotypes. In 2009, a novel 'two-compartment metabolic coupling' model, also named 'the reverse Warburg effect', was proposed and attracted lots of attention. Based on this new model, we consider whether this new viewpoint can be exploited for improving the existent anti-cancer therapeutic strategies. Our review focuses on the paradigm shift from 'the Warburg effect' to 'the reverse Warburg effect', the features and molecular mechanisms of 'the reverse Warburg effect', and then we discuss its significance in fundamental researches and clinical practice.
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