Journal
ONCOTARGET
Volume 8, Issue 59, Pages 100640-100647Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.22062
Keywords
malignant pleural mesothelioma; hyperthermic intrathoracic chemotherapy; meta-analysis
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Surgery-based multimodality therapies have been used to control the malignant effusion and its recurrence in malignant pleural mesothelioma (MPM). Hyperthermic intrathoracic chemotherapy (HITHOC) has been used in the treatment of malignant pleural mesothelioma, but the results were controversial. The aim of the current study was, therefore, to conduct a systematic review and meta-analysis on the effect of HITHOC on MPM therapy. After thorough searching of online databases, total 21 articles were included into qualitative systematic review and 5 of them were used to conduct qualitative meta-analysis. It was found that most of HITHOC was used in combination of surgical resection including extrapleural pneumonectomy or pleurectomy/decortication. Patients who received HITHOC had significantly longer median survival length compared to the patients without HITHOC (Hedges's g = 0.384 +/- 0.105, 95% CI: 0.178 similar to 0.591, P < 0.001). In addition, HITHOC as palliative therapy was favored (Hedges's g = 0.591 +/- 0.201, 95% CI: 0.196 similar to 0.967, P < 0.001) in terms of recurrence free interval. The findings of the current study suggested that HITHOC is one of the safe and effective therapies in prolonging patients' median survival time and extending recurrence free interval.
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