Journal
CHINESE JOURNAL OF CANCER
Volume 52, Issue -, Pages -Publisher
SUN YAT SEN UNIV MED SCI WHO
DOI: 10.1186/s40880-017-0219-2
Keywords
Autophagy; Drug resistance; Neoplasms; Cell survival; Cell death
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Funding
- Science and Technology Program of China [2012ZX09103101-053]
- Natural Science Foundation of Guangdong Province [S2013050014183, 2013CXZDA006]
- Program for New Century Excellent Talents in University
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
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Multidrug resistance (MDR) occurs frequently after long-term chemotherapy, resulting in refractory cancer and tumor recurrence. Therefore, combatting MDR is an important issue. Autophagy, a self-degradative system, universally arises during the treatment of sensitive and MDR cancer. Autophagy can be a double-edged sword for MDR tumors: it participates in the development of MDR and protects cancer cells from chemotherapeutics but can also kill MDR cancer cells in which apoptosis pathways are inactive. Autophagy induced by anticancer drugs could also activate apoptosis signaling pathways in MDR cells, facilitating MDR reversal. Therefore, research on the regulation of autophagy to combat MDR is expanding and is becoming increasingly important. We summarize advanced studies of autophagy in MDR tumors, including the variable role of autophagy in MDR cancer cells.
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