Journal
ONCOTARGET
Volume 8, Issue 6, Pages 10425-10436Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.14425
Keywords
near infrared photoimmunotherapy; immunogenic cell death
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Funding
- Intramural Research Program of the National Institutes of Health, National Cancer Institute
- Center for Cancer Research
- National Institute of Biomedical Imaging and Bioengineering
- PREST, Japan Science and Technology Agency.
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Immunogenic cell death (ICD) is a form of cell death that activates an adaptive immune response against dead-cell-associated antigens. Cancer cells killed via ICD can elicit antitumor immunity. ICD is efficiently induced by near-infrared photo-immunotherapy (NIR-PIT) that selectively kills target-cells on which antibody-photoabsorber conjugates bind and are activated by NIR light exposure. Advanced live cell microscopies showed that NIR-PIT caused rapid and irreversible damage to the cell membrane function leading to swelling and bursting, releasing intracellular components due to the influx of water into the cell. The process also induces relocation of ICD bio markers including calreticulin, Hsp70 and Hsp90 to the cell surface and the rapid release of immunogenic signals including ATP and HMGB1 followed by maturation of immature dendritic cells. Thus, NIR-PIT is a therapy that kills tumor cells by ICD, eliciting a host immune response against tumor.
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