Journal
CHIRALITY
Volume 29, Issue 7, Pages 340-347Publisher
WILEY
DOI: 10.1002/chir.22710
Keywords
1,1 '-binaphthalene-2-naphthol; chiral stationary phase; high performance liquid chromatography; in situ crosslinking polymerization; surface molecularly imprinted polymers
Funding
- National Natural Science Foundation of Heilongjiang Province [E2016019]
- Fundamental Research Funds for the Central Universities [HEUCF20161004, HEUCFQ1417]
- National Natural Science Foundation of China [21576060, 21076049, 21574033]
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Acrylamide (AM) was copolymerized with ethylene glycol dimethacrylate (EGDMA) in the presence of (R)-1,1'-binaphthalene-2-naphthol (BINOL) as the template molecules on the surface of silica gel by a free radical polymerization to produce a chiral stationary phase based on the surface molecularly imprinted polymer (SMIP-CSP). The SMIP-CSP showed a much better separation factor (alpha = 4.28) than the CSP based on the molecularly imprinted polymer (MIP-CSP) without coating on the silica gel (alpha = 1.96) during the chiral separation of BINOL enantiomers by high-performance liquid chromatography. The influence of the pretreatment temperature and the content of the template molecule ((R)-BINOL) of the SMIP-CSP, and the mobile phase composition on the separation of the racemic BINOL were systematically investigated.
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