Journal
ONCOTARGET
Volume 8, Issue 47, Pages 83261-83269Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.18743
Keywords
prostate cancer; tumor-associated macrophages; macrophage scavenger receptor 1; prognosis; meta-analysis
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Funding
- Cancer Research UK through a CRUK Career Development Award [C49791/A17367]
- Chinese Scholarship Council
- MRC Centre grant [MR/N022556/1]
- Cancer Research UK [17367] Funding Source: researchfish
- Medical Research Council [MR/N022556/1] Funding Source: researchfish
- MRC [MR/N022556/1] Funding Source: UKRI
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Recent studies suggested that the tumour associated macrophages may be associated with prostate cancer outcome. A meta-analysis was performed to evaluate the prognostic value of tumor associated macrophages and macrophage scavenger receptor 1, marker for a subset of macrophages, by pooled hazard ratio and 95% confidence intervals from qualified studies following a systemic search. The results indicate that higher infiltration of tumor associated macrophages predicts poor overall survival (HR=1.57, 95% CI: 1.15-1.98), but not biochemical recurrence (HR=1.01, 95% CI: 0.98-1.04) or recurrence-free survival (HR=1.03, 95% CI: 0.05-2.01). In contrast, elevated level of macrophage scavenger receptor 1 was significantly associated with better recurrence-free survival (HR=3.26, 95% CI: 1.22-5.29). Thus, our analysis confirmed the prognostic value of these markers in prostate cancer outcome. We also discussed potential causes of the controversies in the literature and future research directions.
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