Journal
ONCOTARGET
Volume 8, Issue 27, Pages 43953-43966Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.16693
Keywords
SNORD47; glioblastoma; cell cycle; proliferation; invasion
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Funding
- National High Technology Research and Development Program863 [2014AA021102, 2016YFC0902502]
- China National Natural Scientific Found [81372703]
- National Natural Science Foundation of China [81660420]
- construction plan of the superior science and technology innovation team of Jiangxi Province [20152BCB24009]
- foreign science and technology cooperation plan of Jiangxi Province [20151BDH80009]
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SNORD47 is a member of the C/D box small nucleolar RNAs, which have been implicated in cancer development. We intended to investigate the therapeutic potential of SNORD47 in glioma. We found that the expression of SNORD47 was downregulated in glioma tissues samples and inversely associated with advanced tumor stage (WHO grade IV). Kaplan-Meier survival analysis revealed that glioma patients with high SNORD47 expression had longer overall survival than those with low SNORD47 expression. SNORD47 suppressed the proliferation of glioma cells and induced G2 phase arrest. In addition, upregulation of SNORD47 suppressed invasion and epithelial-mesenchymal transition in glioma cells, and combination treatment with lenti-SNORD47 could augment the antitumor effect of temozolomide. These results showed that SNORD47 acted as a tumor suppressor in glioma, and provided the potential anti-tumor function in glioma treatment.
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