Journal
NEUROPSYCHIATRIC DISEASE AND TREATMENT
Volume 13, Issue -, Pages 1509-1519Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/NDT.S136122
Keywords
hippocampus; prefrontal cortex; cognition; depression; Alzheimer's disease
Categories
Funding
- US Public Health Service grant [MH106640]
- Sioux Falls VA Healthcare system
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Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology. The goal of this review is to shed light on the contributions of this circuit to cognitive dysfunction in neuropsychiatric disorders, focusing on Alzheimer's disease and depression.
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