4.7 Article

Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent

Journal

CLINICAL INFECTIOUS DISEASES
Volume 65, Issue 1, Pages 150-153

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cix245

Keywords

leishmaniasis; post-kala-azar dermal leishmaniasis; control; xenodiagnosis

Funding

  1. World Health Organization Special Programme for Research and Training in Tropical Diseases, Switzerland
  2. Spanish Foundation for International Cooperation, Health and Social Affairs
  3. icddr,b core donors

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We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post-kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection and treatment are important missing components of the kala-azar elimination program.

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