Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 48, Pages 6432-6435Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc03587j
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Funding
- National Natural Science Foundation of China (NSFC) [21576085, 21475044]
- Shanghai Municipal Natural Science Foundation [15ZR1409000]
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A fluorescence off-on'' probe CBF, constructed by incorporating a dioxaborine unit into a microenvironment-sensitive fluorophore, was developed for serum albumin (SA). Upon binding to SA, the dioxaborine group in CBF was hydrolyzed into beta-diketonate, which triggered dramatic fluorescence enhancement (over 1000-fold) along with a remarkable blue-shift (similar to 100 nm). The bioimaging results suggested that more SA were taken in by cancer cells.
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