Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 48, Pages 6476-6479Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc03040a
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Funding
- National Natural Science Foundation of China [21371082]
- Natural Science Foundation of Jiangsu Province [BK20141102, BK20151118]
- 333 Project of Jiangsu Province [BRA2016518]
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A kit-like F-18-fluorination method has been successfully applied to prepare an activatable probe 1 with good radiochemical yield and high specific activity. The probe has good in vitro stability and favorable cell membrane permeability. A controlled condensation reaction was initiated, and self-assembly into nanoparticles occurred when the probe was in a reducing environment. Positron emission tomography (PET) imaging of the biothiol level in living subjects was conveniently and precisely realized using this probe. The present study may provide a new platform for the development of smart'' PET tracers for tumor imaging.
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