Journal
CRYSTAL GROWTH & DESIGN
Volume 17, Issue 6, Pages 3277-3286Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.cgd.7b00255
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Funding
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [206093/2014-4]
- Engineering and Physical Sciences Research Council [EP/I033459/1] Funding Source: researchfish
- EPSRC [EP/I033459/1] Funding Source: UKRI
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A data set consisting of structures and aqueous solubility and melting point data for 51 salt forms of the phenylethylamine base methylephedrine is presented. Analysis showed correlation between solubility and melting point and between melting point of the salt and melting-point of the parent acid, but no correlation of salt solubility with-solubility of the parent acid. Identification of associations was aided by examining chemically sensible subgroups of the data set, and this approach highlighted significantly different relationships between solubility and melting point for these subgroups. Thus, for example the expected negative correlation between solubility and melting point Was found for 24 anhydrous benzoate salts, but a positive correlation observed for eight halide salts. Hydrated-forms were anomalous. Packing analysis identified groups of structures that were isostructural with respect to cation packing. Correlation between solubility and melting point was found to be greatest within these isostructural groups, implying a role for packing structure in determining solubility.
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