Journal
BIOFACTORS
Volume 43, Issue 3, Pages 379-387Publisher
WILEY
DOI: 10.1002/biof.1346
Keywords
piceatannol; C; elegans; lifespan; daf-16
Funding
- National Institute of Food and Agriculture
- U.S. Department of Agriculture
- Massachusetts Agricultural Experiment Station
- Department of Food Science
- University of Massachusetts Amherst [MAS00450, MAS00492]
- NIH Office of Research Infrastructure Programs [P40 OD010440]
- China Scholarship Council
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Piceatannol is a natural stilbene with many beneficial effects, such as antioxidative, anti-inflammatory, antiatherogenic activities; however, its role on aging is not known. In this study, we used Caenorhabditis elegans as an animal model to study the effect of piceatannol on its lifespan and investigated the underlying mechanisms. The results showed that 50 and 100 mu M piceatannol significantly extended the lifespan of C. elegans without altering the growth rate, worm size and progeny production. Piceatannol delayed the age-related decline of pumping rate and locomotive activity, and protected the worms from heat and oxidative stress. This study further indicated that lifespan extension and enhanced stress resistance induced by piceatannol requires DAF-16. Since DAF-16 is conserved from nematodes to mammals, our study may have important implications in utilizing piceatannol to promote healthy aging and combat age-related disease in humans. (c) 2016 BioFactors, 43(3):379-387, 2017
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