Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 45, Issue -, Pages 89-96Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2017.03.004
Keywords
-
Categories
Funding
- National Health and Medical Research Council (NHMRC) project [1057707]
- NHMRC Career Development Fellowship
- National Health and Medical Research Council of Australia [1057707] Funding Source: NHMRC
Ask authors/readers for more resources
Vaccine success relies on the formation of immunity. Humoral immunity is critical and is mediated by long-lived antibody-secreting cells and memory B cells (MBCs). Chronic infectious diseases cause a significant global burden of disease; pathogens that evade the immune system can cause phenotypical and functional changes to immune memory populations. Thus, recent studies have focused on MBC subset function. IgM(+) MBCs have emerged as important early responders in malaria. Atypical MBCs have functional qualities associated with exhaustion in chronic infectious diseases, but the requirements for their formation and whether they localize remains unknown. Similarly, the T-bet-driven transcriptional regulation drives formation of MBCs phenotypically similar to atypical MBCs. Identifying protective or detrimental roles of MBC subsets, and their regulators, will be important for clinical intervention.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available