Journal
CRITICAL CARE
Volume 21, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13054-017-1713-2
Keywords
Acute kidney injury; Delayed; Early; Intensive care unit; Renal replacement therapy; Timing
Categories
Funding
- TR15, CAKS, National Research Program for Biopharmaceuticals, Taiwan, ROC
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Renal replacement therapy (RRT) is a key component in the management of severe acute kidney injury (AKI) in critically ill patients. Many cohort studies, meta-analyses, and two recent large randomized prospective trials which evaluated the relationship between the timing of RRT initiation and patient outcome remain inconclusive due to substantial differences in study design, patient population, AKI definition, and RRT indication. A cause-specific diagnosis of AKI based on current staging criteria plus a sensitive biomarker (panel) that allows creating a homogeneous study population is definitely needed to assess the impact of early versus late initiation of RRT on patient outcome.
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