Journal
ANALYST
Volume 142, Issue 12, Pages 2090-2093Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7an00202e
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An innovative chemical strategy integrated in a miniaturized electrochemical device was developed for sensitive detection of a pathogen genome (HBV virus) without any amplification step. The results show a limit of detection comparable to the standard qRT-PCR method (20 copies per reaction), paving the way to future development of genetic PoC devices addressing automatized and low-cost molecular diagnostics.
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