Journal
CELL
Volume 170, Issue 1, Pages 114-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2017.06.008
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Funding
- National Science Foundation of China (NSFC) [31171622, 31571994]
- Program for New Century Excellent Talents in University from the Ministry of Education in China [NECT-13-0920]
- National Key Research and Development Program of China [2016YFD0100600]
- Transgenic Projects from the Chinese Ministry of Agriculture (TPCMA) [2014ZX0800903B]
- NSFC [31501627, 31601290, 31401351]
- Key Project of Sichuan Education Department [15ZA0020]
- DOE Joint BioEnergy Institute - U.S. Department of Energy [DE-AC02-05CH11231]
- TPCMA [2016ZX08001002]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1237975] Funding Source: National Science Foundation
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Rice feeds half the world's population, and rice blast is often a destructive disease that results in significant crop loss. Non-race-specific resistance has been more effective in controlling crop diseases than race-specific resistance because of its broad spectrum and durability. Through a genome-wide association study, we report the identification of a natural allele of a C2H2-type transcription factor in rice that confers non-race-specific resistance to blast. A survey of 3,000 sequenced rice genomes reveals that this allele exists in 10% of rice, suggesting that this favorable trait has been selected through breeding. This allele causes a single nucleotide change in the promoter of the bsr-d1 gene, which results in reduced expression of the gene through the binding of the repressive MYB transcription factor and, consequently, an inhibition of H2O2 degradation and enhanced disease resistance. Our discovery highlights this novel allele as a strategy for breeding durable resistance in rice.
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