Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 329, Issue -, Pages 200-204Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2017.05.015
Keywords
Bitter taste; Olfaction; Smell; Olfactory binding protein; Individual differences; PROP
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Funding
- National Institutes of Health (NIH) [UL1 TR000448, KL2 TR000450]
- NIH [P30 DK05634 (NIH DK 56341)]
- USDA National Institute of Food and Agriculture Hatch Project [698-921]
- NIDCD [P30DC011735]
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Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.
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