Journal
ONCOTARGET
Volume 8, Issue 42, Pages 73017-73028Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.20318
Keywords
GRP78; gastric cancer; meta analysis; bioinformatics analysis
Categories
Funding
- Liaoning BaiQianWan Program
- Award for Liaoning Distinguished Professor
- Key Scientific and Technological Project of Liaoning Province [2015408001]
- National Natural Scientific Foundation of China [81472544, 81672700]
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GRP78 is a molecular chaperone located in endoplasmic reticulum, and induces folding and assembly of newly-synthesized proteins, proteasome degradation of aberrant proteins, and translocation of secretory proteins, autophagy, and epithelialmesenchymal transition. We performed a systematic meta-and bioinformatics analysis through multiple online databases up to March 14, 2017. It was found that up-regulated GRP78 expression in gastric cancer, compared with normal mucosa at both protein and mRNA levels (p < 0.05). GRP78 expression was positively correlated with depth of invasion, TNM staging and dedifferentiation of gastric cancer (p < 0.05), while its mRNA expression was negatively correlated with depth of invasion, histological grading and dedifferentiation (p < 0.05). A positive association between GRP78 expression and unfavorable overall survival was found in patients with gastric cancer (p < 0.005). A higher GRP78 mRNA expression was positively correlated with overall and progression-free survival rates of all cancer patients, even stratified by aggressive parameters, or as an independent factor (p < 0.05). These findings indicated that GRP78 expression might be employed as a potential marker to indicate gastric carcinogenesis and subsequent progression, even prognosis.
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