Journal
ONCOTARGET
Volume 8, Issue 36, Pages 60581-60588Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.19943
Keywords
Fluorine-18 labeled amino acids; positron emission tomography/computed tomography (PET/CT); tumor metabolism; molecular imaging
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Funding
- Natural Science Foundation of China [NSFC81172133, NSFC81372413]
- Special Fund for Scientific Research in the Public Interest [201402011]
- Projects of Medical and Health Technology Development Program in Shandong Province [2014WS0058]
- Outstanding Youth Natural Science Foundation of Shandong Province [JQ201423]
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Tumor glucose metabolism and amino acid metabolism are usually enhanced, F-18-FDG for tumor glucose metabolism PET imaging has been clinically well known, but tumor amino acid metabolism PET imaging is not clinically familiar. Radiolabeled amino acids (AAs) are an important class of PET/CT tracers that target the upregulated amino acid transporters to show elevated amino acid metabolism in tumor cells. Radiolabeled amino acids were observed to have high uptake in tumor cells but low in normal tissues and inflammatory tissues. The radionuclides used in labeling amino acids include O-15, N-13, C-11, I-123, F-18 and Ga-68, among which the most commonly used is F-18 [1]. Available data support the use of certain F-18-labeled AAs for PET/CT imaging of gliomas, neuroendocrine tumors, prostate cancer and breast cancer [2, 3]. With the progress of the method of F-18 labeling AAs [4-6], F-18-labeled AAs are well established for tumor PET/CT imaging. This review focuses on the current status of key clinical applications of 18F-labeled AAs in tumor PET/CT imaging.
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