Journal
ONCOTARGET
Volume 8, Issue 46, Pages 81369-81376Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.18759
Keywords
non-small cell lung cancer; epidermal growth factor receptor; tyrosine kinase inhibitors; bone metastasis; skeletal related events
Categories
Funding
- National Health and Family Planning Commission of PRC [201402031]
- National Natural Science Foundation [81272618]
Ask authors/readers for more resources
Background : Bone metastasis and skeletal related events (SREs) are common in non-small cell lung cancer (NSCLC). Patients with mutant epidermal growth factor receptor (EGFR) could benefit from tyrosine kinase inhibitors (TKIs). However, it is unclear whether SRE is influenced by EGFR status. We aimed to evaluate the correlation of EGFR status and TKIs with the incidence of SREs. Methods : We conducted a retrospective study of stage IV NSCLC patients with bone metastasis. Incidence rate of SREs was collected and was compared using chi-square test. Logistic-regression analysis was used to identify the risk factors predicting the incidence of SREs. Results : 410 eligible patients were enrolled in the study. 49.0% were detected with EGFR mutation. 49.8% of patients received EGFR-TKIs therapy prior to the onset of SREs. 42.7% experienced at least one SRE. Patients who were treated with TKIs held lower incidence of SREs than patients who were not treated with TKIs (23.5% vs 61.7%, p<0.001). Multivariate analysis showed that poor performance status (OR 5.550, 95% CI 2.290-13.450; p<0.001) and mutant EGFR (OR 3.050, 95% CI 1.608-5.787, p=0.001) were independent risk factors predicting the onset of SREs, while the usage of TKIs (OR 0.102, 95% CI 0.054-0.193, p<0.001) was a protective factor of SREs in NSCLC patients with bone metastasis. Conclusions : This study indicates that the incidence of SREs is common in both patients with and without EGFR mutation. Poor performance ability and mutant EGFR imply higher risks of SREs, while the usage of TKIs may be a protective factor of SREs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available