Journal
ONCOTARGET
Volume 8, Issue 39, Pages 65414-65420Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.18676
Keywords
hepatic ischemia reperfusion injury; curcumin; TLR4; NF-kappa B; inflammatory cytokine
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Funding
- Beijing high level health personnel training program [2013-3-074]
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The TLR4/NF-kappa B pathway had important roles in hepatic ischemia/reperfusion (I/R) injury. In this study, we reported a protective effect of curcumin against hepatic I/R injury via TLR4/NF-kappa B pathway. Curcumin significantly inhibited cell apoptosis, and decreased levels of LDH and production of TNF-alpha, IL-1b, and IL-6 in the cell supernatant. In addition, curcumin ameliorated elevated TLR4 and NF-kappa B caused by hypoxia/reoxygenation stimulation in BRL-3A cells. In vivo assays revealed that curcumin reduce levels of ALT and AST, and reversed TLR4/NF-kappa B signaling pathway caused by hepatic I/R stimulation in liver tissues. These results suggested that curcumin ameliorates hepatic I/R injury, which may be mediated in part via the TLR4/NF-kappa B signaling pathway.
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