Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 65, Issue 7, Pages 612-617Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c17-00068
Keywords
drug delivery system; liposome; hyperthermia; stimuli-triggered release; cancer therapy
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- JSPS
- Mochida Memorial Foundation
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Significant progress has been achieved in the development of stimuli-responsive nanocarriers for drug delivery, diagnosis, and therapy. Various types of triggers are utilized in the development of nanocarrier delivery. Endogenous factors such as changes in pH, redox, gradient, and enzyme concentration which are linked to disease progression have been utilized for controlling biodistribution and releasing drugs from nanocarriers, as well as increasing subsequent pharmacological activity at the disease site. Nanocarriers which respond to artificially-induced exogenous factors (such as temperature, light, magnetic field, and ultrasound) have also been developed. This review aims to discuss recent advances in the design of stimuli-responsive nanocarriers which appear to have a promising future in medicine.
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