Journal
ONCOTARGET
Volume 8, Issue 25, Pages 41717-41733Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.16684
Keywords
breast cancer; exosome; metastasis; drug resistance; cancer therapy
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Funding
- National Natural Science Foundation of China [81602471, 81672729, 8167284]
- Natural Science Foundation of Zhejiang Province [Q16H160010]
- China National Program on Key Basic Research Project (973 Program) [2014CB744505]
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Exosomes are nano-sized membrane vesicles released by a variety of cell types, and are thought to play important roles in intercellular communications. In breast cancer, through horizontal transfer of various bioactive molecules, such as proteins and mRNAs, exosomes are emerging as local and systemic cell-to-cell mediators of oncogenic information and play an important role on cancer progression. This review outlines the current knowledge and concepts concerning the exosomes involvement in breast cancer pathogenesis (including tumor initiation, invasion and metastasis, angiogenesis, immune system modulation and tumor microenvironment) and cancer therapy resistance. Moreover, the potential use of exosomes as promising diagnostic and therapeutic biomarkers in breast cancer are also discussed.
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