Journal
ONCOTARGET
Volume 8, Issue 16, Pages 26269-26280Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.15447
Keywords
PCAF; GCN5; telomere recombination; ALT
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Funding
- Commissariat a l'Energie Atomique et aux Energies Alternatives [Programme Plasticite et Instabilite des Genomes]
- Commissariat a l'Energie Atomique et aux Energies Alternatives [IRTELIS PhD program]
- La Ligue Nationale Contre le Cancer
- La Fondation de France
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Cancer cells can use a telomerase-independent mechanism, known as alternative lengthening of telomeres (ALT), to elongate their telomeres. General control non-derepressible 5 (GCN5) and P300/CBP-associated factor (PCAF) are two homologous acetyltransferases that are mutually exclusive subunits in SAGA-like complexes. Here, we reveal that down regulation of GCN5 and PCAF had differential effects on some phenotypic characteristics of ALT cells. Our results suggest that GCN5 is present at telomeres and opposes telomere recombination, in contrast to PCAF that may indirectly favour them in ALT cells.
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