Journal
ALZHEIMERS & DEMENTIA
Volume 13, Issue 7, Pages 727-738Publisher
WILEY
DOI: 10.1016/j.jalz.2016.12.012
Keywords
Transethnic; Alzheimer's disease; Genome-wide association; APOE interaction
Categories
Funding
- National Institutes of Health, National Institute on Aging (NIH-NIA) [U01 AG032984, RC2 AG036528, U01 AG016976, U24 AG021886, U24 AG026395, U24 AG026390, MIRAGE: R01 AG025259, P30 AG019610, P30 AG013846]
- NINDS [NS39764]
- NIMH [MH60451]
- GlaxoSmithKline
- Kronos Science
- NIA [AG034504]
- Banner Alzheimer's Foundation
- Johnnie B. Byrd Sr. Alzheimer's Institute
- Medical Research Council
- State of Arizona
- NHS trusts
- Newcastle University
- Higher Education Funding Council for England
- Alzheimer's Research Trust ART
- BRACE
- North Bristol NHS Trust Research and Innovation Department
- DeN-DRoN
- Stichting MS Research
- Brain Net Europe
- Hersenstichting Nederland Breinbrekend Werk
- International Parkinson Fonds
- Internationale Stiching Alzheimer Onderzoek
- Institut de Neuropatologia
- Servei Anatomia Patologica
- Universitat de Barcelona
- Abbott
- AstraZeneca AB
- Bayer Schering Pharma AG
- Bristol-Myers Squibb
- Eisai Global Clinical Development
- Elan Corporation
- Genentech
- GE Healthcare
- Innogenetics
- Johnson and Johnson
- Eli Lilly and Co.
- Medpace
- Merck Co., Inc.
- Novartis AG
- Pfizer
- F. Homan-La Roche
- Schering-Plough
- Synarc
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Dana Foundation
- National Institute of Biomedical Imaging and Bioengineering
- NIA grants [U01 AG024904, RC2 AG036535, K01 AG030514]
- Alzheimer's Association [IIRG-08-89720, IIRG-05-14147]
- US Department of Veterans Affairs Administration, Office of Research and Development, Biomedical Laboratory Research Program
- Wellcome Trust
- Howard Hughes Medical Institute
- Canadian Institute of Health
- The National Institutes of Health, National Institute on Aging (NIH-NIA) [P50 AG005146, R01 AG020688, P50 AG005134, P50 AG016574, P50 AG005138, P01 AG002219, P30 AG08051, MO1RR00096, UL1 RR029893, P30 AG013854, P30 AG008017, R01 AG026916, P30 AG010161, R01 AG15819, R01 AG17917, R01 AG30146, R01 NS059873, P50 AG016582, UL1RR02777, R01 AG031581, P30 AG010129, P50 AG016573]
- National Institutes of Health, National Institute on Aging (NIH-NIA). [AG027944, AG021547, AG019757, P50 AG005136, R01 AG019085, P50 AG005681, P01 AG03991, U01 AG10483, R01 CA129769, R01 MH080295, R01 AG017173, R01 AG33193, R01 AG048927, P50 AG008702, R37 AG015473, P30 AG028377, AG05128, AG025688, UO1 AG06781, UO1 HG004610, U01 HG006375, P30 AG10133]
- .National Institutes of Health, National Institute on Aging (NIH-NIA) [P50 P50 AG016575, P50 AG016576, P50 AG016577, P50 AG016570, P50 AG005131, P50 AG023501, P01 AG019724, P30 AG028383, P50 AG008671, P30 AG010124, P50 AG005133, AG030653, P50 AG005142, P30 AG012300, R01 AG027944, AG010491]
- Grants-in-Aid for Scientific Research [16K14649] Funding Source: KAKEN
- MRC [MR/J004758/1, G1001253, G0901254, G0701075, MR/K01417X/1] Funding Source: UKRI
Ask authors/readers for more resources
Introduction: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. Methods: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. Results: Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)based tests (P < 5 x 10(-8)) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE epsilon 4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 x 10(-6)) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 x 10(-6)). Discussion: Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci. (C) 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
