Journal
ONCOTARGET
Volume 8, Issue 13, Pages 21567-21578Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.15372
Keywords
obstructive sleep apnea syndrome; lung cancer; big data platform
Categories
Funding
- National Natural Science Foundation of China [71673254, 81603122]
- National Science & Technology Huimin Program [2013GS410101]
- Major Program of Science & Technology of Henan Province [121100111100]
- Innovation Scientists and Technicians Troop Construction Projects of Henan Province [144100510017]
- Basic and Advanced Technology Research Foundation from Science and Technology Department of Henan Province [122300410155]
- Funds for Creative Research Team of Henan Province
- Creative Research Team of Higher Education of Henan Province
- Innovation Team of the First Affiliated Hospital of Zhengzhou University
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Based on our hospital database, the incidence of lung cancer diagnoses was similar in obstructive sleep apnea Syndrome (OSAS) and hospital general population; among individual with a diagnosis of lung cancer, the presence of OSAS was associated with an increased risk for mortality. In the gene expression and network-level information, we revealed significant alterations of molecules related to HIF1 and metabolic pathways in the hypoxic-conditioned lung cancer cells. We also observed that GBE1 and HK2 are downstream of HIF1 pathway important in hypoxia-conditioned lung cancer cell. Furthermore, we used publicly available datasets to validate that the late-stage lung adenocarcinoma patients showed higher expression HK2 and GBE1 than early-stage ones. In terms of prognostic features, a survival analysis revealed that the high GBE1 and HK2 expression group exhibited poorer survival in lung adenocarcinoma patients. By analyzing and integrating multiple datasets, we identify molecular convergence between hypoxia and lung cancer that reflects their clinical profiles and reveals molecular pathways involved in hypoxic-induced lung cancer progression. In conclusion, we show that OSAS severity appears to increase the risk of lung cancer mortality.
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