Journal
ONCOTARGET
Volume 8, Issue 16, Pages 26079-26089Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.15317
Keywords
PTENP1; miR-106b; miR-93; long non-coding RNA; gastric cancer
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Funding
- National Natural Science Foundation of China [81572416]
- Tianjin Natural Science Funds [15JCYBJC54500]
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Recent studies have shown that competing endogenous RNAs (ceRNAs) play an important role in the regulation of gene expression, and participate in a wide range of biological processes, including carcinogenesis. Long non-coding RNA PTENP1, the pseudogene of PTEN tumor suppressor, has been reported to exert its tumor suppressive function via modulation of PTEN expression in many malignancies. However, whether a PTENP1 similar to miRNA similar to PTEN ceRNA network exists and how it functions in gastric cancer (GC) remains elusive. In order to identify and characterize the PTENP1 similar to miRNA similar to PTEN ceRNA network in GC, we first determined PTENP1 levels in clinical GC samples and found that PTENP1 and PTEN were concurrently downregulated in these samples. We further demonstrated that PTENP1 could act as a ceRNA to sponge miR-106b and miR-93 from targeting PTEN for downregulation using a novel ceRNA in vitro gradient assay. Thus, we revealed a tumor suppressive role of PTENP1 as ceRNA in GC and pinpointed the specific miRNAs decoyed by PTENP1, highlighting the emerging roles of ceRNAs in the biological regulation of GC cells and their possible clinical significance.
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