Journal
ONCOTARGET
Volume 8, Issue 21, Pages 34164-34176Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.15878
Keywords
long non-coding RNA; PVT1; LASP1; miR-203; esophageal squamous cell carcinoma
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Funding
- National Natural Science Foundation of China [81502697]
- Natural Science Foundation of Hubei Province [2016CFB374]
- Wu Jie Pin Medical Foundation [01-08-530059]
- Independent Innovation Research Foundation of Huazhong University of Science and Technology [01-08-530059]
- Union Hospital Key Laboratory Foundation of Biological Target Therapy [02.03.2013-80]
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Long non-coding RNAs are a group of non-coding RNAs longer than 200 nucleotides and possess diverse functions and exhibit exquisite cell-specific and developmental dynamic expression patterns. The role of the long non-coding RNA PVT1 in esophageal squamous cell carcinoma remains unsolved. Here, we showed that PVT1 expression is significantly up-regulated in ESCC tumor samples compared with their normal counterparts. Knockdown of PVT1 suppressed tumor growth in vitro and in vivo. Further studies revealed that silence of PVT1 lead to up-regulation of miR-203, and vice versa. Moreover, LASP1 was found to be downregulated after knockdown of PVT1 and overexpression of LASP1 attenuated the tumor-suppressive roles of PVT1 knockdown. Our results suggest that PVT1 promote ESCC progression via functioning as a molecular sponge for miR-203 and LASP1 and provide the first evidence of dysregulated PVT1/miR-203/LASP1 axis in ESCC.
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