Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 63, Issue -, Pages 210-223Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2016.10.022
Keywords
Neonatal; Inflammation; Brain injury; Peripheral immune; Hypoxia-ischemia
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Funding
- Swedish Research Council [2012-2992]
- Government grant in Public Health Service at the Sahlgrenska University Hospital [ALFGBG-142881]
- Leducq Foundation [DSRR_P34404]
- Swedish Brain Foundation [FO2014-008]
- Ahlen Foundation
- Torsten Soderberg Foundation [M98/15]
- Action Medical Research [2485] Funding Source: researchfish
- Medical Research Council [G0802853] Funding Source: researchfish
- MRC [G0802853] Funding Source: UKRI
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The perinatal period has often been described as immune deficient. However, it has become clear that immune responses in the neonate following exposure to microbes or as a result of tissue injury may be substantial and play a role in perinatal brain injury. In this article we will review the immune cell composition under normal physiological conditions in the perinatal period, both in the human and rodent. We will summarize evidence of the inflammatory responses to stimuli and discuss how neonatal immune activation, both in the central nervous system and in the periphery, may contribute to perinatal hypoxic-ischemic brain injury. (C) 2016 Elsevier Inc. All rights reserved.
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