Journal
ONCOTARGET
Volume 8, Issue 19, Pages 31718-31726Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.15954
Keywords
TIM-3; meta-analysis; solid tumor; prognostic marker; overall survival
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Funding
- National Natural Science Foundation of China [81372259, 81200020]
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Accumulated studies have demonstrated the important role of T cell immunoglobulinand mucin-domain-containing molecule-3 (TIM-3) in various solid tumors and indicated its correlation with patients' survival. To further verify the prognostic significance of TIM-3 in cancer patients and its correlation with tumor, we performed this meta-analysis including seven studies searched from PubMed, Web of Science, and Embase till July 2016. A total of 869 patients were used to analyze the association between TIM-3 expression and patients' overall survival (OS). The pooled results showed that higher expression of TIM-3 was significantly correlated to shorter OS (7 studies, HR=1.89; 95% CI: 1.38-2.57; P< 0.001). In addition, higher TIM-3 expression was associated with advanced tumor stage (3 studies, III/IV vs. I/II, RR= 2.02; 95% CI: 1.45-2.81; P< 0.001). In conclusion, our study highlights the role of TIM-3 as a potential prognostic marker and a promising therapeutic target in solid tumors.
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