Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 74, Issue 13, Pages 2345-2360Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2473-5
Keywords
Mesenchymal stem cell; Inflammation; Immune regulation; Plasticity
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Funding
- China National Basic Research Program [JFYS 2016YFA0100203]
- National Natural Science Foundation of China [31272518, 31572399]
- Program of the Shaanxi Province [2015NY157]
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In addition to being multi-potent, mesenchymal stem cells (MSCs) possess immunomodulatory functions that have been investigated as potential treatments in various immune disorders. MSCs can robustly interact with cells of the innate and adaptive immune systems, either through direct cell-cell contact or through their secretome. In this review, we discuss current findings regarding the interplay between MSCs and different immune cell subsets. We also draw attention to the mechanisms involved.
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