Journal
CLINICAL INFECTIOUS DISEASES
Volume 65, Issue 1, Pages 158-161Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cix014
Keywords
ceftolozane; carbapenem resistant; P. aeruginosa; multidrug resistant
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Funding
- National Institute of Allergy and Infectious Diseases [R01 AI093749, R21 AI114961, R01 AI089891, R01 AI100560, R01 AI063517]
- Cleveland Department of Veterans Affairs Merit Review Program [1I01BX001974]
- Chilean Government, Clinica Alemana-Universidad del Desarrollo
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A multicenter, retrospective study of patients infected with carbapenem-resistant Pseudomonas aeruginosa who were treated with ceftolozane/tazobactam was performed. Among 35 patients, pneumonia was the most common indication and treatment was successful in 26 (74%). Treatment failure was observed in all cases where isolates demonstrated ceftolozane-tazobactam minimum inhibitory concentrations >= 8 mu g/mL.
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